In the constant pursuit of longevity and health optimization, few metrics are as underappreciated yet as profoundly important as ApoB. While cholesterol has long been part of the public conversation, the real marker of cardiovascular risk lies deeper—in the number of particles carrying that cholesterol through your bloodstream. That’s what ApoB measures: the concentration of a protein present on all atherogenic lipoproteins, the particles that drive plaque formation in arteries.
Why does this matter? Because heart disease remains the leading cause of death worldwide, and most of us underestimate our risk until it’s too late. ApoB gives us a sharper lens—it doesn’t just tell us about cholesterol quantity, but about the vehicles transporting it, the ones that can slip beneath arterial walls and silently build the foundation for disease. In essence, ApoB reveals not just what’s in the bloodstream, but how many potential culprits are at work.
Bryan Johnson frames this in terms of proactive self-care: don’t wait for decline, measure early, measure often, and intervene intelligently. Peter Attia echoes this with relentless clarity—ApoB is not optional data, it’s essential. The earlier you know where you stand, the more power you have to alter the trajectory of your health.
Checking ApoB regularly is not just a number on a lab test—it is a commitment to vigilance, to responsibility, and to giving yourself the chance to live not just longer, but better. For anyone serious about healthspan, ApoB belongs at the top of your list.
This essay draws inspiration from the work and insights of Bryan Johnson and Peter Attia.